Publications

Pearn, K., Allen, M., Laws, A., Monks, T., Everson, R., & James, M. (2023). What would other emergency stroke teams do? Using explainable machine learning to understand variation in thrombolysis practice. MedRxiv. https://doi.org/10.1101/2023.04.24.23289017

Toffoli, M., Chohan, H., Mullin, S., Jesuthasan, A., Yalkic, S., Koletsi, S., Menozzi, E., Rahall, S., Limbachiya, N., Loefflad, N., Higgins, A., Bestwick, J., Lucas-Del-Pozo, S., Fierli, F., Farbos, A., Mezabrovschi, R., Lee-Yin, C., Schrag, A., Moreno-Martinez, D., … Schapira, A. H. V. (2023). Phenotypic effect of GBA1 variants in individuals with and without Parkinson’s disease: The RAPSODI study. Neurobiology of Disease, 188, 106343. https://doi.org/10.1016/j.nbd.2023.106343

Foltynie, T., Gandhi, S., Gonzalez-Robles, C., Zeissler, M.-L., Mills, G., Barker, R., Carpenter, J., Schrag, A., Schapira, A., Bandmann, O., Mullin, S., Duffen, J., McFarthing, K., Chataway, J., Parmar, M., Carroll, C., & the EJS ACT-PD Consortium . (2023). Towards a multi-arm multi-stage platform trial of disease modifying approaches in Parkinson’s disease. Brain, 146(7), 2717–2722. https://doi.org/10.1093/brain/awad063

Timme, M., Viktorov, J., Steffens, L., Streeter, A., Karch, A., & Schmeling, A. (2023). Dental age assessment in the living: a comparison of two common stage classifications for assessing radiographic visibility of the root canals in mandibular third molars. International Journal of Legal Medicine. https://doi.org/10.1007/s00414-023-03121-y

Wulms, N., Eppe, S., Dehghan Nayyeri, M., Streeter, A., Bonberg, N., Berger, K., Sundermann, B., & Minnerup, H. (2023). The R package for DICOM to brain imaging data structure conversion. Scientific Data, 10. https://doi.org/10.1038/s41597-023-02583-4

Abstracts of ICPE 2023, the 39th International Conference on Pharmacoepidemiology and Therapeutic Risk Management (ICPE), Halifax, Canada, 25–27 August 2023. (2023). Pharmacoepidemiology and Drug Safety, 32(S1), 3–612. https://doi.org/https://doi.org/10.1002/pds.5687

Russell, T. B., Labib, P. L., Ausania, F., Pando, E., Roberts, K. J., Kausar, A., Mavroeidis, V. K., Marangoni, G., Thomasset, S. C., Frampton, A. E., Lykoudis, P., Maglione, M., Alhaboob, N., Bari, H., Smith, A. M., Spalding, D., Srinivasan, P., Davidson, B. R., Bhogal, R. H., … Aroori, S. (2023). Serious complications of pancreatoduodenectomy correlate with lower rates of adjuvant chemotherapy: Results from the recurrence after Whipple’s (RAW) study. European Journal of Surgical Oncology, 49(9), 106919. https://doi.org/https://doi.org/10.1016/j.ejso.2023.04.018

Russell, T. B., Labib, P. L., Denson, J., Ausania, F., Pando, E., Roberts, K. J., Kausar, A., Mavroeidis, V. K., Marangoni, G., Thomasset, S. C., Frampton, A. E., Lykoudis, P., Maglione, M., Alhaboob, N., Bari, H., Smith, A. M., Spalding, D., Srinivasan, P., Davidson, B. R., … Paterna-López, S. (2023). Predictors of actual five-year survival and recurrence after pancreatoduodenectomy for ampullary adenocarcinoma: results from an international multicentre retrospective cohort study. HPB, 25(7), 788–797. https://doi.org/https://doi.org/10.1016/j.hpb.2023.03.010

Lambert, J., Taylor, A., Streeter, A., Greaves, C., Ingram, W. M., Dean, S., Jolly, K., Mutrie, N., Price, L., & Campbell, J. (2023). Adding web-based support to exercise referral schemes improves symptoms of depression in people with elevated depressive symptoms: A secondary analysis of the e-coachER randomised controlled trial. Mental Health and Physical Activity, 25, 100535. https://doi.org/https://doi.org/10.1016/j.mhpa.2023.100535

Timme, M., Viktorov, J., Steffens, L., Streeter, A., Karch, A., & Schmeling, A. (2023). Third molar eruption in orthopantomograms as a feature for forensic age assessment-a comparison study of different classification systems. International Journal of Legal Medicine, 137. https://doi.org/10.1007/s00414-023-02982-7

Taylor, A. H., Thompson, T. P., Streeter, A., Chynoweth, J., Snowsill, T., Ingram, W., Ussher, M., Aveyard, P., Murray, R. L., Harris, T., Callaghan, L., Green, C., Greaves, C. J., Price, L., & Creanor, S. (2023). Effectiveness and cost-effectiveness of behavioural support for prolonged abstinence for smokers wishing to reduce but not quit: Randomised controlled trial of physical activity assisted reduction of smoking (TARS). Addiction, 118(6), 1140–1152.

MacCormick, A., Streeter, A., Puckett, M., & Aroori, S. (2023). The impact of myosteatosis on outcomes following surgery for gastrointestinal malignancy: a meta-analysis. The Annals of The Royal College of Surgeons of England, 105(3), 203–211. https://doi.org/10.1308/rcsann.2021.0290

Tanase, A., Dhanda, A., Cramp, M., Streeter, A., & Aroori, S. (2023). Laparoscopic Common Bile Duct Exploration: Results From a Prospective Multi-centre Prospective UK-wide Study (P-ALiCE). HPB, 25, S264–S265.

Tanase, A., Dhanda, A., Cramp, M., Streeter, A., & Aroori, S. (2023). Outcomes of Laparoscopic Common Bile Duct Exploration: Results from a Multi-centre UK-wide Study (R-ALiCE). HPB, 25, S211.

Allen, M., James, C., Frost, J., Liabo, K., Pearn, K., Monks, T., Everson, R., Stein, K., & Martin James. (2022). Use of Clinical Pathway Simulation and Machine Learning to Identify Key Levers for Maximizing the Benefit of Intravenous Thrombolysis in Acute Stroke. Stroke, 53(9), 2758–2767. https://doi.org/10.1161/STROKEAHA.121.038454

Courtman, M., Thurston, M., McGavin, L., Caroll, C., Sun, L., Ifeachor, E., & Mullin, S. (2022). 095 Artificial Intelligence based detection of Parkinson’s disease in magnetic resonance imaging brain scans. Journal of Neurology, Neurosurgery & Psychiatry, 93, e2.45. https://doi.org/10.1136/jnnp-2022-abn2.139

Thurston, M. D. V., Kim, D. H., & Wit, H. K. (2022). Neural Network Detection of Pacemakers for MRI Safety. Journal of Digital Imaging, 35(6), 1673–1680. https://doi.org/10.1007/s10278-022-00663-2

Toffoli, M., Chen, X., Sedlazeck, F. J., Lee, C.-Y., Mullin, S., Higgins, A., Koletsi, S., Garcia-Segura, M. E., Sammler, E., Scholz, S. W., Schapira, A. H. V., Eberle, M. A., & Proukakis, C. (2022). Comprehensive short and long read sequencing analysis for the Gaucher and Parkinson’s disease-associated GBA gene. Communications Biology, 5(1), 670. https://doi.org/10.1038/s42003-022-03610-7

Courtman, M., Thurston, M., McGavin, L., Caroll, C., Sun, L., Ifeachor, E., & Mullin, S. (2022). 095 Artificial Intelligence based detection of Parkinson’s disease in magnetic resonance imaging brain scans. Journal of Neurology, Neurosurgery & Psychiatry, 93(9), e2. https://doi.org/10.1136/jnnp-2022-abn2.139

Streeter. (2022). Real-world effectiveness of pneumococcal vaccination in older adults: Cohort study using the UK Clinical Practice Research Datalink. PLOS ONE, 17(10), 1–13. https://doi.org/10.1371/journal.pone.0275642

Lambert, J., Taylor, A., Streeter, A., Greaves, C., Ingram, W. M., Dean, S., Jolly, K., Mutrie, N., Taylor, R. S., Yardley, L., Price, L., & Campbell, J. (2022). A process evaluation, with mediation analysis, of a web-based intervention to augment primary care exercise referral schemes: the e-coachER randomised controlled trial. International Journal of Behavioral Nutrition and Physical Activity, 19(1), 128. https://doi.org/10.1186/s12966-022-01360-7

Elston, J., Gradinger, F. P., Streeter, A. J., Macey, S., & Martin, S. (2022). Effectiveness of a targeted telephone-based case management service on activity in an Emergency Department in the UK: a pragmatic difference-in-differences evaluation. BMC Health Services Research, 22(1), 1038. https://doi.org/10.1186/s12913-022-08415-2

Streeter, A., Rodgers, L., Hamilton, F., Masoli, J., Ble, A., Hamilton, W., & Henley, W. (2022). Influenza vaccination reduced myocardial infarctions in UK older adults: a prior event rate ratio study. J Clin Epidemiol. https://doi.org/10.1016/j.jclinepi.2022.06.018

Tanase, A., Dhanda, A., Cramp, M., Streeter, A., & Aroori, S. (2022). A UK survey on variation in the practice of management of choledocholithiasis and laparoscopic common bile duct exploration (ALiCE Survey). Surgical Endoscopy, 36(8), 5882–5896. https://doi.org/10.1007/s00464-021-08983-0

Allen, M., Pearn, K., Ford, G., White, P., Rudd, A., Mcmeekin, P., Stein, K., & James, M. (2021). National implementation of reperfusion for acute ischaemic stroke in England: How should services be configured? A modelling study. European Stroke Journal, 7, 239698732110633. https://doi.org/10.1177/23969873211063323

McMeekin, P., Flynn, D., James, M., Price, C. I., Ford, G. A., & White, P. (2021). Updating estimates of the number of UK stroke patients eligible for endovascular thrombectomy: incorporating recent evidence to facilitate service planning. European Stroke Journal, 6(4), 349–356. https://doi.org/10.1177/23969873211059471

Mcmeekin, P., Flynn, D., James, M., Price, C., Ford, G., & White, P. (2021). Updating estimates of the number of UK stroke patients eligible for endovascular thrombectomy: incorporating recent evidence to facilitate service planning. European Stroke Journal, 6, 239698732110594. https://doi.org/10.1177/23969873211059471

Al-Nuaimi, A. H., Blūma, M., Al-Juboori, S. S., Eke, C. S., Jammeh, E., Sun, L., & Ifeachor, E. (2021). Robust EEG Based Biomarkers to Detect Alzheimer’s Disease. Brain Sciences, 11(8). https://doi.org/10.3390/brainsci11081026

Eke, C. S., Jammeh, E., Li, X., Carroll, C., Pearson, S., & Ifeachor, E. (2021). Early Detection of Alzheimer’s Disease with Blood Plasma Proteins Using Support Vector Machines. IEEE Journal of Biomedical and Health Informatics, 25(1), 218–226. https://doi.org/10.1109/JBHI.2020.2984355

Kim, D., Wit, H., Thurston, M., Long, M., Maskell, G., Strugnell, M., Shetty, D., Smith, I., & Hollings, N. (2021). An artificial intelligence deep learning model for identification of small bowel obstruction on plain abdominal radiographs. The British Journal of Radiology, 94(1122), 20201407. https://doi.org/10.1259/bjr.20201407

Higgins, A. L., Toffoli, M., Mullin, S., Lee, C.-Y., Koletsi, S., Avenali, M., Blandini, F., & Schapira, A. H. (2021). The remote assessment of parkinsonism supporting the ongoing development of interventions in Gaucher disease. Neurodegenerative Disease Management, 11(6), 451–458. https://doi.org/10.2217/nmt-2021-0032

Avenali, M., Cerri, S., Cerami, C., Crespi, C., Gegg, M., Mullin, S., Toffoli, M., Hughes, D., Valente, E., Tassorelli, C., Schapira, A., & Blandini, F. (2021). Combined GCASE/ALPHA-synuclein pattern may identify specific prodomal PD patterns in GBA carriers: A cluster analysis study. Journal of the Neurological Sciences, 429. https://doi.org/10.1016/j.jns.2021.119455

Toffoli, M., Higgins, A., Lee, C., Koletsi, S., Chen, X., Eberle, M., Sedlazeck, F. J., Mullin, S., Proukakis, C., & Schapira, A. H. V. (2021). Intronic Haplotypes in the GBA Gene Do Not Predict Age at Diagnosis of Parkinson’s Disease. Movement Disorders, 36(6), 1456–1460. https://doi.org/https://doi.org/10.1002/mds.28616

Talbot, J., Stuckey, R., Crawford, L., Weatherby, S., & Mullin, S. (2021). Improvements in pain, medication use and quality of life in onabotulinumtoxinA-resistant chronic migraine patients following erenumab treatment – real world outcomes. The Journal of Headache and Pain, 22(1), 5. https://doi.org/10.1186/s10194-020-01214-2

Mullin, S., Stokholm, M. G., Hughes, D., Mehta, A., Parbo, P., Hinz, R., Pavese, N., Brooks, D. J., & Schapira, A. H. V. (2021). Brain Microglial Activation Increased in Glucocerebrosidase (GBA) Mutation Carriers without Parkinson’s disease. Movement Disorders, 36(3), 774–779. https://doi.org/https://doi.org/10.1002/mds.28375

Timme, M., Borkert, J., Nagelmann, N., Streeter, A., Karch, A., & Schmeling, A. (2021). Age-dependent decrease in dental pulp cavity volume as a feature for age assessment: a comparative in vitro study using 9.4-T UTE-MRI and CBCT 3D imaging. International Journal of Legal Medicine, 135(4), 1599–1609. https://doi.org/10.1007/s00414-021-02603-1

Jones, B. G., Streeter, A. J., Baker, A., Moyeed, R., & Creanor, S. (2021). Bayesian statistics in the design and analysis of cluster randomised controlled trials and their reporting quality: a methodological systematic review. Systematic Reviews, 10(1), 91. https://doi.org/10.1186/s13643-021-01637-1

Tomlinson, D. R., Biscombe, K., True, J., Hosking, J., & Streeter, A. J. (2021). Identification of deliberate catheter motion at the left atrial posterior wall during pulmonary vein isolation: Validity of respiratory motion adjustment. Journal of Cardiovascular Electrophysiology, 32(4), 994–1004. https://doi.org/https://doi.org/10.1111/jce.14945

Rodgers. (2021). Impact of influenza vaccination on amoxicillin prescriptions in older adults: A retrospective cohort study using primary care data. PLOS ONE, 16(1), 1–13. https://doi.org/10.1371/journal.pone.0246156

Mullin, S., Smith, L., Lee, K., D’Souza, G., Woodgate, P., Elflein, J., Hällqvist, J., Toffoli, M., Streeter, A., Hosking, J., Heywood, W. E., Khengar, R., Campbell, P., Hehir, J., Cable, S., Mills, K., Zetterberg, H., Limousin, P., Libri, V., … Schapira, A. H. V. (2020). Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations: A Nonrandomized, Noncontrolled Trial. JAMA Neurology, 77(4), 427–434. https://doi.org/10.1001/jamaneurol.2019.4611

Barakabitze, A. A., Mkwawa, I.-H., Hines, A., Sun, L., & Ifeachor, E. (2020). QoEMultiSDN: Management of Multimedia Services using MPTCP/SR in Softwarized and Virtualized Networks. IEEE Access, 1–1. https://doi.org/10.1109/ACCESS.2020.3039953

Tiele, A., Wicaksono, A., Daulton, E., Ifeachor, E., Eyre, V., Clarke, S., Timings, L., Pearson, S., Covington, J. A., & Li, X. (2020). Breath-based non-invasive diagnosis of Alzheimer’s disease: a pilot study. Journal of Breath Research, 14(2), 026003. https://doi.org/10.1088/1752-7163/ab6016

Babiloni, C., Blinowska, K., Bonanni, L., Cichocki, A., De Haan, W., Del Percio, C., Dubois, B., Escudero, J., Fernández, A., Frisoni, G., Guntekin, B., Hajos, M., Hampel, H., Ifeachor, E., Kilborn, K., Kumar, S., Johnsen, K., Johannsson, M., Jeong, J., … Randall, F. (2020). What electrophysiology tells us about Alzheimer’s disease: a window into the synchronization and connectivity of brain neurons. Neurobiology of Aging, 85, 58–73. https://doi.org/https://doi.org/10.1016/j.neurobiolaging.2019.09.008

Wyatt, K., Lloyd, J., Creanor, S., Green, C., Dean, S., Hillsdon, M., Abraham, C., Tomlinson, R., Pearson, V., Taylor, R., Ryan, E., Streeter, A., Forbes, C., Hurst, A., Price, L., Crathorne, L., Krägeloh, C., Siegert, R., & Logan, S. (2018). Cluster randomised controlled trial and economic and process evaluation to determine the effectiveness and cost-effectiveness of a novel intervention [Healthy Lifestyles Programme (HeLP)] to prevent obesity in school children. Public Health Research, 6, 1–204. https://doi.org/10.3310/phr06010

Taylor, A., Thompson, T. P., Ussher, M., Aveyard, P., Murray, R. L., Harris, T., Creanor, S., Green, C., Streeter, A. J., Chynoweth, J., Ingram, W., Greaves, C. J., Hancocks, H., Snowsill, T., Callaghan, L., Price, L., Horrell, J., King, J., Gude, A., … Preece, D. (2020). Randomised controlled trial of tailored support to increase physical activity and reduce smoking in smokers not immediately ready to quit: protocol for the Trial of physical Activity-assisted Reduction of Smoking (TARS) Study. BMJ Open, 10(12). https://doi.org/10.1136/bmjopen-2020-043331

Taylor, A., Taylor, R., Ingram, W., Dean, S., Jolly, K., Mutrie, N., Lambert, J., Yardley, L., Streeter, A., Greaves, C., Mcadam, C., Price, L., Anokye, N., & Campbell, J. (2020). Randomised controlled trial of an augmented exercise referral scheme using web-based behavioural support for inactive adults with chronic health conditions: the e-coachER trial. British Journal of Sports Medicine, 55. https://doi.org/10.1136/bjsports-2020-103121

Taylor, A. H., Taylor, R. S., Ingram, W. M., Anokye, N., Dean, S., Jolly, K., Mutrie, N., Lambert, J., Yardley, L., Greaves, C., King, J., McAdam, C., Steele, M., Price, L., Streeter, A., Charles, N., Terry, R., Webb, D., Campbell, J., … Cavanagh, C. (2020). Adding web-based behavioural support to exercise referral schemes for inactive adults with chronic health conditions: the e-coachER RCT. 24, 63. https://doi.org/10.3310/hta24630

Tan, H., Streeter, A., Cramp, M., & Dhanda, A. (2020). Effect of zinc treatment on clinical outcomes in patients with liver cirrhosis: A systematic review and meta-analysis. World Journal of Hepatology, 12, 390–399. https://doi.org/10.4254/wjh.v12.i7.390

Mullin, S., Smith, L., Lee, K., D’Souza, G., Woodgate, P., Elflein, J., Hällqvist, J., Toffoli, M., Streeter, A., Hosking, J., Heywood, W. E., Khengar, R., Campbell, P., Hehir, J., Cable, S., Mills, K., Zetterberg, H., Limousin, P., Libri, V., … Schapira, A. H. V. (2020). Ambroxol for the Treatment of Patients With Parkinson Disease With and Without Glucocerebrosidase Gene Mutations: A Nonrandomized, Noncontrolled Trial. JAMA Neurology, 77(4), 427–434. https://doi.org/10.1001/jamaneurol.2019.4611

Allen, M., Pearn, K., Monks, T., Bray, B. D., Everson, R., Salmon, A., James, M., & Stein, K. (2019). Can clinical audits be enhanced by pathway simulation and machine learning? An example from the acute stroke pathway. BMJ Open, 9(9). https://doi.org/10.1136/bmjopen-2018-028296

Avenali, M., Toffoli, M., Mullin, S., McNeil, A., Hughes, D. A., Mehta, A., Blandini, F., & Schapira, A. H. V. (2019). Evolution of prodromal parkinsonian features in a cohort of GBA mutation-positive individuals: a 6-year longitudinal study. Journal of Neurology, Neurosurgery & Psychiatry, 90(10), 1091–1097. https://doi.org/10.1136/jnnp-2019-320394

Leija-Salazar, M., Sedlazeck, F. J., Toffoli, M., Mullin, S., Mokretar, K., Athanasopoulou, M., Donald, A., Sharma, R., Hughes, D., Schapira, A. H. V., & Proukakis, C. (2019). Evaluation of the detection of GBA missense mutations and other variants using the Oxford Nanopore MinION. Molecular Genetics & Genomic Medicine, 7(3), e564. https://doi.org/https://doi.org/10.1002/mgg3.564

Barakabitze, A. A., Sun, L., Mkwawa, I.-H., & Ifeachor, E. (2019). A Novel QoE-Aware SDN-enabled, NFV-based Management Architecture for Future Multimedia Applications on 5G Systems.

Tomlinson, D. R., Myles, M., Stevens, K. N., & Streeter, A. J. (2019). Transmural unipolar electrogram change occurs within 7 s at the left atrial posterior wall during pulmonary vein isolation. Pacing and Clinical Electrophysiology, 42(7), 922–929. https://doi.org/https://doi.org/10.1111/pace.13729

Ammoun, S., Evans, D., Hilton, D., Streeter, A., Hayward, C., & Hanemann, C. (2019). Phase 0 trial investigating the intratumoural concentration and activity of sorafenib in neurofibromatosis type 2. Journal of Neurology, Neurosurgery & Psychiatry, 90, jnnp-2018. https://doi.org/10.1136/jnnp-2018-319713

Kim, D. H., Wit, H., & Thurston, M. (2018). Artificial intelligence in the diagnosis of Parkinson’s disease from ioflupane-123 single-photon emission computed tomography dopamine transporter scans using transfer learning. Nuclear Medicine Communications, 39(10), 887–893. https://doi.org/10.1097/MNM.0000000000000890

Eke, C. S., Jammeh, E., Li, X., Carroll, C., Pearson, S., & Ifeachor, E. (2018). Identification of Optimum Panel of Blood-based Biomarkers for Alzheimer’s Disease Diagnosis Using Machine Learning. 2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 3991–3994. https://doi.org/10.1109/EMBC.2018.8513293

Jammeh, E. A., Camille, B. C., Stephen, W. P., Escudero, J., Anastasiou, A., Zhao, P., Chenore, T., Zajicek, J., & Ifeachor, E. (2018). Machine-learning based identification of undiagnosed dementia in primary care: a feasibility study. BJGP Open, 2(2).

Al-Nuaimi, A. H. H., Jammeh, E., Sun, L., & Ifeachor, E. (2018). Complexity Measures for Quantifying Changes in Electroencephalogram in Alzheimer’s Disease. Complexity, 2018, 1–12. https://doi.org/10.1155/2018/8915079

Haslam, C., Damiati, S., Whitley, T., Davey, P., Ifeachor, E., & Awan, S. A. (2018). Label-Free Sensors Based on Graphene Field-Effect Transistors for the Detection of Human Chorionic Gonadotropin Cancer Risk Biomarker. Diagnostics, 8(1). https://doi.org/10.3390/diagnostics8010005

Wyatt, K., Lloyd, J., Creanor, S., Green, C., Dean, S., Hillsdon, M., Abraham, C., Tomlinson, R., Pearson, V., Taylor, R., Ryan, E., Streeter, A., Forbes, C., Hurst, A., Price, L., Crathorne, L., Krägeloh, C., Siegert, R., & Logan, S. (2018). Cluster randomised controlled trial and economic and process evaluation to determine the effectiveness and cost-effectiveness of a novel intervention [Healthy Lifestyles Programme (HeLP)] to prevent obesity in school children. Public Health Research, 6, 1–204. https://doi.org/10.3310/phr06010

Churilov, L., & Donnan, G. (2012). Operations Research for stroke care systems: An opportunity for The Science of Better to do much better. Operations Research for Health Care, 1, 6–15. https://doi.org/10.1016/j.orhc.2011.12.001